Children and adolescents are in the rapid and critical period of growth and development, and are more sensitive to various external influences than adults. The high incidence of mental illness in children and adolescents is between the ages of 9 and 15, which coincides with this critical period of development. Childhood schizophrenia is a serious mental illness that develops in adolescence and must be treated promptly, and early detection and intervention is very favorable to the prognosis. The use of medication is the most important of all treatments. Especially in the acute phase of the disease. As the old saying goes, “all drugs are poisonous”, you need to pay attention to the possible side effects during the use of drugs, and regularly check the blood routine, liver and kidney function, endocrine, electrocardiogram and so on. In the acute stage, 1~2 times per month, and in the recovery stage, 1 time per month or every 2 months. Some parents can still adhere to it at first, but they slacken off after a period of time. Although the chances of side effects are very small, especially in recent years, the emergence of some new drugs has effectively reduced the risk of medication, but more attention can always avoid unnecessary trouble. Scientific, rational and compliant use of medication is a must.