The clinical manifestations of hyperthyroidism vary, especially in patients in the early stages of the disease or with mild symptoms, and the various symptoms and signs are not very typical. The typical clinical manifestations of hyperthyroidism may include one or more of the following: 1. hypermetabolic syndrome: fear of heat, excessive sweating, red, warm, moist skin, emaciation, muscle weakness, easy fatigue, etc. 2. 2, symptoms of increased excitability of the nervous system: hypersensitivity, excitability, impatience, insomnia, dreaminess, lack of concentration of thought, and fine tremor when the hands are stretched flat. A fine tremor of the tongue can be seen when the tongue is extended. 3. Enlargement of the thyroid gland: mostly bilateral diffuse enlargement, soft or medium hardness of the gland, moving up and down with swallowing movements. Because of the dilated blood vessels and accelerated blood flow in the gland, vascular murmurs can be heard locally and tremors can be felt on palpation. A few patients may have nodule formation (usually benign nodules). 4. Protrusion of the eye: there are two types of protrusion: benign protrusion and malignant protrusion, and the former accounts for most of the protrusions. The former accounts for the majority of proptosis. It is usually bilateral, occasionally unilateral, or protrudes first in one eye and then in the other. Benign proptosis is mainly characterized by widening of the eye fissure, straight staring of both eyes, and little blinking. In malignant proptosis, there is foreign body sensation, stinging pain, photophobia, tearing, diplopia, limited eye movement, difficulty in closing the upper and lower eyelids, exposure of the cornea, corneal congestion, inflammation, and ulceration. In severe cases, corneal ulcers can be perforated, causing total ophthalmia and even blindness. 5. Cardiovascular system symptoms: Most patients have palpitations and tachycardia, and rapid heart rate during sleep is the characteristic performance of hyperthyroidism. Some patients have chest tightness, shortness of breath, elevated systolic blood pressure, normal or reduced diastolic blood pressure, and increased pulse pressure difference. The first heart sound in the apical region is hyperactive and a blowing systolic murmur can be heard. Atrial fibrillation may occur in some patients, and heart failure may occur in very serious patients. 6, digestive system symptoms: hyperphagia, meal quantity is significantly more than normal. Diarrhea, increased frequency of stools, 2-4 times a day. The liver and spleen may be mildly enlarged. Some patients develop jaundice and increased transaminases. 7, motor system symptoms: often have varying degrees of muscle weakness, muscle wasting, muscle atrophy, the occurrence of generalized muscle atrophy, known as chronic hyperthyroidism myopathy. It can also be accompanied by periodic paralysis and myasthenia gravis. 8, gonadal dysfunction: male patients may appear impotence, female patients may appear menstrual scarcity, irregular, etc.. 9. Skin: A few patients may develop mucinous edema of the limbs, or/and other skin changes.