I. Translated name: Bing-Neel syndrome II. Bing-Neel syndrome can be divided into diffuse type and tumor type. In the former, tumor cells are mainly distributed in the soft meningeal space, the white matter of the brain around the ventricles, the pons and the medulla, and manifest as non-localized neurological abnormalities, such as personality changes, decreased cognitive level, and brain accumulation with high cranial pressure, and imaging is usually negative. The latter often has locoregional symptoms or seizures, and imaging usually yields positive results. Etiology: The etiology is unknown and may be related to toxin infection, with widespread diffuse neurological changes, especially in the spinal cord, optic nerve, and pontine brain, showing signs of toxic an infectious neurogenic, meningeal, and spinal cord lesions. V. Ocular features: 1. Visual impairment (depending on the extent of retinal damage), ptosis, and extraocular muscle paralysis. 2, glaucoma. Mild optic papilloedema, chorioretinitis, retinal hemorrhage, retinal vein segmental dilatation, vascular curvature, peripheral microaneurysm, occasional macular degeneration and retinal detachment. Systemic features: 1. chronic brain lesions, cerebral hemorrhage, stroke, subarachnoid hemorrhage, polyneuritis, and mucosal hemorrhage. 2. Mildly elevated body temperature. Pale face, enlarged lymph nodes, splenomegaly, dyspnea, weakness of limbs, weight loss, loss of appetite. 3. Different degrees of paralysis due to disseminated spinal cord lesions and vasospasm of the extremities. 4. Laboratory tests: anemia, increased blood sedimentation, macroglobulinemia, hyperproteinemia, increased blood viscosity, proteinuria, tubuluria, and excess IgM. VII. Treatment: The ideal treatment should be radiotherapy combined with chemotherapy.