Multiple sclerosis (MS) is a typical representative of demyelinating diseases of the central nervous system, characterized clinically by a wide range of lesions and a large number of attacks, and pathologically by inflammatory demyelination of the central nervous system, which is named because of the repeated attacks and the formation of sclerotic plaques. Epidemiology shows that the disease is prevalent between 15 and 50 years old, mainly affecting young adults, with acute or subacute onset, relapsing remission, and progressive development, mainly involving the optic nerve, subcortical white matter, and spinal cord. MS is often classified as relapsing remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), etc. MS causes dysfunction of the central nervous system. The management of MS is further complicated by its disease course. There is no specific drug for MS, but the drugs used in clinical practice only relieve symptoms, reduce relapses and slow down the progression of the disease. Treatment principles: stop disease progression, reduce relapse, prolong remission period, shorten relapse period, actively prevent various complications, pay attention to life care, and improve the quality of survival. Symptomatic treatment 1. Spasticity state (1) Mild spasticity state: exercise can be strengthened, such as performing hydrotherapy, yoga or physical therapy. MS patients who appear stiff, spastic or clonic are given: baclofen 10-40mg, 3 times/d, high dose can cause weakness and fatigue; tizanidine 2-8mg, 3 times/d, high dose can cause weakness and fatigue; gabapentin 300-900mg, 3-4 times/d, high dose can cause fatigue. (2) Difficult to deal with spasticity: Intrathecal baclofen treatment was performed (replacing the original chemical nerve rhizotomy and spinal cord dissection). 2, pain and paroxysmal dysfunction Carbamazepine 100mg, 3 times/d, monitor complete blood count and liver function; Gabapentin 300-900mg, 3-4 times/d, high dose can cause fatigue; Carbamazepine (Tegretol), 100-600mg, 3 times/d, high dose can cause skin rash and neurological Toxic side effects. Monitoring of complete blood count and liver function is required. Other antitussive drugs: Amitriptyline (Elavil), 10~150mg/d at bedtime. 3, urinary urgency Ohxibutynin (Oxybutynin, Ditropan), 5mg, 1 time / d, increase to 20mg / d, divided into 2-4 times, can cause dry mouth, aggravate glaucoma and urinary retention; Toleterodine (Toleterodine, Detrol), 2-4mg, 2 times / d, can cause dry mouth, aggravate glaucoma and urinary retention (less than Oh The side effects of xibunin are less). 4, depression Patients with MS with mild depressive symptoms: the use of psychological support can alleviate symptoms. MS patients with severe depression: pentazocine reuptake inhibitors (SSRIs) are preferred, and if side effects occur, venlafaxine (venlafaxine, Effexor), 75 mg to 225 mg/d; or bupropion (bupropion, Wellbutrin), 150 mg, 2 times/d. If sleep disturbances occur, or if accompanied by headache can be given: almiterol 10-150mg/d, taken at bedtime. 5, fatigue Amantadine Symmetrel, 100mg, 2 times/d; can cause rash, edema and anti-sympathetic effects; Modafinil Provigil, 100-200mg, taken in the morning; can cause neurosensitivity and palpitations.