Methotrexate can be used to treat early ectopic pregnancy, but there are certain side effects, patients must go to the hospital after examination, under the guidance of the doctor treatment, do not take the drug arbitrarily. Main effects and side effects: Methotrexate is a chemotherapy drug that can inhibit cell growth and terminate the growth of embryonic tissue. Ectopic pregnancy patients can use methotrexate to kill the embryonic cells attached to the ectopic tissues, so that the HCG value decreases, to achieve the effect of treating ectopic pregnancy. As methotrexate belongs to antitumor drugs, improper use of methotrexate can easily cause some side effects, such as mouth ulcers, leukopenia, thrombocytopenia, alopecia, dark skin pigmentation, as well as nausea, vomiting, diarrhea and other gastrointestinal symptoms. Usage: Methotrexate can be administered systemically or injected directly into the gestational sac under ultrasound guidance, and the specific dosage to be used should be formulated according to the development time of the embryo and the patient’s weight. Methotrexate can also be combined with mifepristone for treatment, which has a synergistic effect, can shorten the course of treatment and reduce side effects. Precautions: 1, the conservative treatment of ectopic pregnancy has certain conditions, firstly, the systemic condition should be good, and secondly, the value of HCG is less than 2000miu/ml, so the general conservative treatment needs to be carried out under the conditions of the doctor’s discernment and hospitalization; 2, if the blood HCG continues not to fall or rise, and the clinical manifestations do not improve, the treatment plan should be changed in time, and sometimes it is necessary to carry out surgical treatment in time in order to avoid the occurrence of Rupture of ectopic pregnancy.