Amoxicillin is mainly used for the treatment of bacterial infectious lesions. Taking amoxicillin does not affect the consumption of alcohol, but it is usually recommended clinically that alcohol should not be consumed while taking the drug. Cephalosporins can react with alcohol in a disulfiram-like manner, with symptoms such as nausea, vomiting, facial flushing, etc. In severe cases, cardiac arrest may occur. Amoxicillin is a penicillin antibiotic and will not react with alcohol biochemically, but drinking alcohol will affect the absorption and utilization of the drug in the body, which is not conducive to the recovery of the disease and will increase the burden on the liver, so it is recommended to refrain from drinking alcohol while taking amoxicillin. In addition, patients should pay more attention to their body after taking amoxicillin in order to detect allergic reactions to the drug as early as possible, and they should ensure sufficient sleep, drink more water and avoid straining during taking the drug.