Beijing Hospital Ophthalmology has routinely performed vitrectomy surgery for many years. With the continuous updating of technical equipment, the hospital now has the most advanced American vitrectomy and cataract ultrasound emulsification all-in-one machine, which can perform cataract and vitreous surgery at the same time, reducing secondary surgery. The surgical instruments for vitrectomy are minimally invasive 25G, 25+. The surgery is performed without sutures, with little trauma, fast prognosis and good results. The following knowledge is presented: I. What are the advantages of minimally invasive vitrectomy? The 25 and 25+ minimally invasive vitrectomy technique can cut the vitreous efficiently and quickly with little side injury. Previous procedures that may require intraocular gas injection or silicone oil injection can be avoided in some cases during minimally invasive surgery for secondary surgery. The postoperative wound does not need to be sutured and removed, reducing the patient’s grinding pain caused by sutures, less pain, significantly shorter surgery time, faster postoperative recovery, and better results. Second, how long to consider surgery after vitreous hemorrhage turbidity mechanization? Usually vitreous hemorrhage for about a month, the absorption of the accumulated blood is not obvious, or repeated bleeding, and it is difficult to see the fundus, consider minimally invasive vitrectomy surgery. In the past, it was thought that the hemorrhage was not absorbed for 3 months before surgery, but often some people have more serious retinal detachment due to hemorrhagic mechanization and poor vision recovery, which makes the surgery relatively complicated and often requires a second surgery. That is why surgery is now recommended for bleeding for about a month. There are many causes of vitreous blood accumulation: common ones are diabetic retinopathy, retinal vein obstruction, posterior vitreous detachment, trauma, age-related macular degeneration, etc. In vitrectomy surgery, combined laser and other treatments should be carried out according to specific diseases. 3.When to do surgery for macular fissure? If macular fissure is detected, especially if the macular fissure is seen in stage 2 or above on the OCT of macular scan machine, it is recommended to operate as soon as possible, otherwise the vision recovery will be worse when the vision loss is obvious. Now Beijing hospital adopts the latest surgical method: minimally invasive vitrectomy combined with inner boundary membrane transplantation + intraocular gas injection, the rate of fissure closure is significantly improved, and the post-operative vision is significantly better. Because intraocular gas injection is needed after macular fissure surgery, the patient needs to sleep on his head in a low position and on his stomach at night for at least three days after surgery, and we hope the patient will cooperate. The vision will recover gradually after the surgery, and it takes half a year to be stable. 4.When should I operate on the macular anterior membrane? If you are checked out to have macular anterior membrane, see things with obvious distortion, and recent vision loss, you can consider minimally invasive vitrectomy + anterior membrane peeling + inner boundary membrane peeling. Without surgery, the distortion of seeing will gradually worsen, and the worse the vision, the less the degree of vision recovery after surgery. It is recommended that you do not wait until your vision is very poor to have surgery. The degree of distortion will gradually decrease after surgery, and the degree of vision recovery will vary and take half a year to gradually stabilize. V. When do I need vitrectomy combined with cataract surgery? 1 If the cataract is obvious after the examination and affects the clarity of the vitreous surgery field. 2 Age over 65, cataract will aggravate with each year, avoid secondary surgery. 3 According to the surgeon’s judgment, whether to implant an IOL in the eye at the same time.