Cryptoglomerulonephritis is generally not serious. However, whether it is serious or not needs to be judged with the condition and treatment effect. If the patient’s condition is mild, or timely treatment, cryptoglomerulonephritis is usually not serious. If the patient’s urine protein increases, high blood pressure and renal function damage, the treatment effect is not good, the condition progresses, and may eventually develop into uremia, which is more serious at this time. Occult nephritis, i.e., asymptomatic hematuria and/or proteinuria, refers to a group of glomerular diseases that manifest only glomerulonephritic hematuria and/or mild-to-moderate proteinuria, not accompanied by edema, hypertension, and renal impairment, and is usually detected and diagnosed through laboratory tests. If the patient’s condition is mild or treated in time, the renal function of most patients can be maintained stable for a long time, and a few patients are cured automatically, at which time cryptogenic nephritis is usually not serious. Some patients have increased urinary protein, hypertension and renal function damage, the treatment effect is not good, with the progression of the disease, it may develop into uremia, which is relatively more serious at this time. Patients with cryptogenic nephritis are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.