Anti-tuberculosis drugs may cause kidney damage, leading to an increase in blood creatinine. Elevated creatinine indicates that there may be some problems with the kidneys. Generally speaking, the kidneys are very capable of compensating. When the kidneys are not damaged to some extent, patients usually have no discomfort. When the glomerular filtration rate drops to more than 50% of normal, blood creatinine begins to rise. Antituberculosis drugs, which usually include aminoglycosides such as streptomycin, amikacin, and kanamycin, are filtered through the kidneys but are not excreted from the renal tubules. They can accumulate in high concentrations in the renal cortical tissue and cause damage to the proximal tubules, which can lead to tubular damage and swelling in mild cases, and severe cases will result in tubular necrosis. Clinical manifestations include proteinuria, progressive hematuria and elevated serum creatinine, again leading to acute renal failure. The degree of nephrotoxicity is usually proportional to the size of the agent. Patients are advised to take anti-tuberculosis drugs under the proper guidance and supervision of a doctor, and if side effects occur, they should go to the hospital in time, and the doctor will take relevant measures for treatment.