The heart and mouth fossa nausea is an atypical clinical symptom, at this time can not exclude the digestive system diseases and cardiovascular diseases. 1, the possible digestive system diseases are mainly esophagitis, gastritis, this may be accompanied by some acid reflux, heartburn and other discomfort, need to improve the gastroscopy and other examinations, after a clear diagnosis, generally take proton pump inhibitors, gastrointestinal power drugs can relieve the corresponding symptoms. 2, possible cardiovascular diseases Coronary artery disease, at this time need to go to the hospital to improve the electrocardiogram, cardiac ultrasound, if necessary to improve the coronary angiography to clarify whether the blood vessels with stenosis and the degree of stenosis, in this case, if the diagnosis is clear, may need anti-platelet aggregation, lipid regulation and stabilization, reduce myocardial oxygen consumption and other treatment, if necessary, also need to perform interventional surgery.