Topical drug therapy for dermatological diseases is simple to operate and economical, which is especially important in the treatment of pediatric dermatological diseases. However, pediatric skin has special physiological characteristics, topical drugs if used improperly will not only affect the therapeutic effect, but also due to overabsorption and poisoning or other side effects, aggravating the condition and increasing pain, so pediatric dermatology should be given great attention when using topical drugs. A, according to the characteristics of pediatric skin selection of topical drug formulations Pediatric skin is thinner than adults, the appearance of flat, tender, fine texture poor resistance, easy to damage, body surface area by kilograms of body weight than adults, the skin heat dissipation, heat consumption, absorption surface is large. Dermatology topical drug formulations are lotions, ointments, tinctures, rubs, powders, hard ointments, coating agents, aerosols, etc. When choosing, you should understand the preparation characteristics of each dosage form, as well as the addition of auxiliary agents, solvents, co-solvents, transdermal absorption enhancers, etc., to avoid adverse reactions. For example, the suspension should not be used for hair parts, the gel can cause dry skin, and the inflamed tissue can cause burning, stinging and itching. According to the state of the lesion and the site of the drug to choose topical drugs Pediatric skin vascular system is quite developed, the vascular network is closer to the epidermis than adults, and its response to the impact of the external environment is also more intense; and skin damage can lead to the loss of the barrier effect of the stratum corneum, so that the speed and degree of transdermal absorption of drugs is greatly enhanced. Such as general skin ulcers, can make the drug permeability more than 3 to 5 times the normal skin, even the original can not be absorbed transdermally substances produce transdermal absorption, thus causing pain, allergies, poisoning and other side effects, so pediatric skin is generally not suitable for the use of more irritating topical drugs. However, the palm, the bottom of the foot because of the thicker stratum corneum and hyaline layer, the lack of hair cortical structure, transdermal absorption ability is poor, the external use of drugs should be increased dose; finger ( toe ) nail external use of drugs more difficult to penetrate, should first soften the nail, or nail pulling, or use a small contusion knife contusion nail plate before using drugs, in order to play a role. The first thing you need to do is to take a look at the actual product. Acute open dermatitis is appropriate to use wet compress method, such as large vesicles oozing then choose the appropriate water solution wet compress to promote its inflammation; can not use paste and ointment agent, because can block the evaporation of water, increase the local temperature, can make the rash aggravated. 2, acute phase: inflammation manifested as small pieces of vesicles, accompanied by a small amount of exudate, also for the scattered papules or the emergence of scales and scabs, generally with paste, such as no vesicular exudate, available lotions, creams, etc.; scabs first applied with ointment, softened and wiped away, and then use topical drugs, so that drugs are easily absorbed. 3, sexual stage: manifested as dryness, thickening, roughness, mossy changes or hyperkeratosis, this period should be selected with ointment or cream, hard cream, etc.. Mossy lesions can also be used as tinctures, which can protect and moisturize the skin, soften the adhesions and make them penetrate deep into the lesions and work. 4, itchy skin disease: attention should be paid to the choice of anti-itch drugs. Anti-itch drugs can generally be divided into two categories: a class of volatile substances, such as camphor, menthol, ice chips, etc.; another class of drugs with local anesthetic effect. Such as carbolic acid, dicaine, benzocaine, etc.. Can be formulated into powder, application, wash, tincture, solution, etc., according to the degree of skin itching are selected. In addition, in the selection of drugs must read the drug instructions in detail, in order to clarify the main components and indications of drugs and possible adverse reactions, according to the specific circumstances of pediatric skin and disease to choose drugs, do not think that the more gorgeous packaging, the more expensive drugs must also be more effective, and do not think that the more complex drug ingredients, the more indications must be suitable for drugs. With the continuous development of pharmaceutical technology, the variety of topical drugs is increasing, the rational and correct use of drugs is more important. In conclusion, when applying topical drugs for pediatric dermatology, we should grasp the physiological and pathological characteristics of children, combine the clinical manifestations of pediatric dermatology, and carefully consider the stage, extent and scope of the disease to choose the concentration of the drug form, application time and method of use. In the process of medication, closely observe the reaction and efficacy of medication, then carefully and flexibly analyze, summarize, adjust, and master the principles of use to achieve the expected best treatment purpose.