Patients undergoing IVF treatment often ask us to do second or even third generation IVF, and we often laugh at this situation. Patients think that, just like cell phones or computers, one generation is better than the other. In fact, the difference is not at all. It is not a difference in the level of technology, but in the way of technology. In simple terms, the difference between 1st generation and 2nd generation is that the sperm and egg are fertilized in a different way. 1st generation is the natural union of sperm and egg, which eventually forms the embryo, while 2nd generation is due to the poor quantity or quality of sperm, which is not enough to combine with the egg naturally, then the doctor helps the sperm and egg to combine through a technique artificially, which eventually forms the embryo. The third generation refers to pre-implantation genetic screening or diagnosis, which is to check the chromosomes of each embryo to see if there are genetic disorders, and the embryos with abnormalities are discarded and the embryos that are not checked for abnormalities are transferred into the uterus, mainly for patients with chromosomal disorders. Therefore, the choice of IVF technique depends entirely on the patient’s different conditions and which one is suitable should be chosen.