Laparoscopic total mesocolic resection of right hemicolonic cancer radical surgery patient’s main cause of right lower abdominal pain and discomfort with wasting for six months, aggravated for more than half a month admitted to the hospital. The patient complained of right lower abdominal discomfort with wasting without obvious triggers, and the colonoscopy suggested that the ascending colon was occupied, and the pathologic biopsy returned colon cancer. The preoperative discussion concluded that the patient’s diagnosis of ascending colon cancer was clear, with indications for surgery and no contraindications for surgery. Since the patient was young and his family had a very positive attitude towards treatment, laparoscopic total mesocolic resection of the right half of the colon was performed for the radical treatment of colon cancer. After general anesthesia, the patient was placed in the supine split-leg position, and the surgical operation was started after comprehensive exploration of the abdominal cavity. The surgical path of separating the right hemicolonic mesentery from the middle approach was selected from the inside to the outside and from the bottom to the top. According to the arterial pulsation, the main trunk of the superior mesenteric vein and the ileocecal pedicle branching to the right side were located in the ascending mesentery. The colonic mesentery and venous sheath were incised immediately anterior to the superior mesenteric vein and dissected cephalad within the sheath in the direction of its course to expose the trunk. The right branches of the superior mesenteric vessels, including the ileocolic vessels, the gastrocolic trunk, and the mesocolic vessels, were gradually exposed and freed during the dissection. The superior mesenteric artery was exposed posteriorly to the left of the superior mesenteric vein while the lymph nodes around the trunk were cleared. The right hemicolonic mesentery was then addressed, and the ascending colonic mesentery was incised immediately to the right of the venous sheath to access the Toldt’s fascial space behind the mesentery. The mesentery was retracted anterolaterally, and using Gerota’s fascia as a guide, the mesentery was freed peripherally within the Toldt’s fascial space to reach the Toldt’s line, where the ascending mesentery meets the lateral abdominal wall; cephaladically, the mesentery was freed to cross the junction of the duodenal descending segment and the horizontal segment, and the head of the pancreas and the duodenum was lifted up, and the posterior lobe of the mesenteric mesentery was separated from the pancreaticoduodenal anterior fascia; cephaladically, the mesentery was released to reach the level of the root margin of the small bowel. Part of the small bowel mesentery was loosened. The mesentery of the right half of the colon was completely freed. Subsequently, the right lateral peritoneum was separated, and the right hemicolon was led to the left side, and the lateral peritoneum of the ascending colon, the posterior peritoneum of the right paracolic sulcus, and the gastrocolic and phrenocolic ligaments were dissected in one go from bottom to top, and the Toldt’s fascial hiatus was accessed again from the outside to make the surgical planes of the central and peripheral sides of the colon completely connected to the mesenteric surfaces that had been previously peeled off. Finally, the right half of the colon was resected and anastomosed. Postoperatively, the patient recovered well and was discharged from the hospital after 1 week, with a good status on follow-up six months later.