Leg ulcers in diabetic patients are caused by lesions of nerves and blood vessels. Leg ulceration in diabetic patients is due to long-term high blood sugar leading to lesions in nerves and blood vessels, which are manifested as sensory abnormalities, atherosclerosis, ischemic stenosis and so on, so they are prone to necrosis and ulceration. Diabetic patients should go to the regular hospital immediately after the occurrence of leg ulceration, the doctor will be based on the patient’s condition for debridement, dressing change and other surgical treatments, to remove the ulcerated tissue, to promote the growth of fresh granulation tissue, as well as anti-infective treatment, commonly used anti-infective drugs have drugs piperacillin sulbactam, ceftriaxone and so on. Diabetic patients with leg ulcers should be treated under the guidance of a doctor.