OBJECTIVE: Traditional upper urinary tract tumors (ureteral and renal pelvis cancers) are long and traumatic to operate. This study investigates the use of fully minimally invasive techniques (laparoscopy and transurethral electrodesiccation) for the treatment of ureteral and renal pelvis cancers to achieve the effect of reducing surgical trauma increasing skin aesthetics and shortening operative time. METHODS: Thirty-one patients with ureteral and renal pelvis cancer, 19 males and 12 females, 14 left and 17 right, came to our hospital because of hematuria. The preliminary diagnosis of ureteral and renal pelvis cancer was clearly made by CTU, ultrasound and CT before surgery. After general anesthesia, the first stage of surgery was performed in a truncated position, and a cystic sleeve resection was performed around the ureteral orifice on the side of the tumor using the hook electrode of the transurethral electrodes to reach the fatty tissue around the bladder, and then a urinary catheter was placed to end the first stage of surgery. The position was reshifted to a lateral position, 3-4 Trocar were placed in the lumbar region after sterilization, and laparoscopic nephrectomy was performed with complete removal of the entire ureter (including the bladder cuff). The complete kidney, the whole ureter and the cuffed bladder specimen were put into the specimen bag to prevent specimen breakage leading to tumor implantation, and then removed out of the body and the operation was finished. RESULTS: So there were all successful surgeries and none of them were converted to open surgery, with less bleeding and faster recovery compared to traditional open surgery. Compared with the two 30cm and 25cm incisions in traditional open surgery, all patients only had a small incision of about 5cm in the waist for specimen removal, and complete removal of the tumor could be achieved during the surgery. Our completely minimally invasive technique for the treatment of ureteral and pelvic carcinoma approach has great advantages. Discussion: The incidence of ureteral and pelvic cancers has been increasing in the last decade. Surgical treatment includes removal of the kidney, ureter and part of the bladder, but traditional surgical resection of upper urinary tract tumors (ureteral and pelvic cancers) is extensive and spans a large area, requiring a 30 cm and 25 cm incision in the lumbar region and a 25 cm incision in the left lower abdomen. Our fully minimally invasive technique for ureteral and renal pelvis cancer approach has great advantages in reducing the pain of patients due to large incisions after surgery and improving the aesthetic appearance of the skin of female patients in particular.