There are various methods for the treatment of bone metastasis, now we will tell you the conventional treatment methods for bone metastatic cancer, because your information is not very comprehensive, please choose the appropriate methods according to the specific conditions of patients, or you can send the detailed information to me, and then give the targeted reply. Non-surgical treatment (1) Radiotherapy: ①Local radiotherapy Local radiotherapy has obvious efficacy in relieving the pain of bone metastases, reducing the occurrence of pathological fracture and alleviating the compression of tumor on spinal cord, etc., and it can obviously improve the quality of survival of patients. Radionuclide therapy, also called internal radiotherapy, is a kind of treatment method with obvious effect, little side effect, non-addictive and has direct killing effect on tumor cells. (2) Chemotherapy: Chemotherapy is another important measure for treating this disease. It mainly applies drugs and chemotherapy programs that are sensitive to the primary tumor. (3) Hormone therapy: certain hormone-sensitive tumors, the application of hormone therapy is beneficial no matter for surgical or non-surgical patients, the effect of hormone therapy is often temporary, but sometimes it can produce long-term effect. Adrenalectomy, ovariectomy, pituitary resection and orchiectomy are often used to treat and prevent metastasis of breast and prostate cancers; for those who can not be operated, injection of hormone-blocking drugs is also effective. (4) Application of bone resorption inhibitor: drugs inhibiting osteoclast activity, such as diphosphate and calcitonin, etc. have certain effect in the treatment of bone metastases. Diphosphonates play a therapeutic role by inhibiting the activity of osteoclasts and blocking the pathologic osteolysis through competition. Calcitonin has the effect of inhibiting osteoclasts, anti-osteolysis and inhibiting bone resorption. (5) Bone cement interventional filling treatment can also be used for patients with bone metastatic cancer, which is mostly used for spinal metastasis without neurological symptoms, such as numbness, pain, irregular urination and defecation of lower limbs, etc. Pelvic and limb metastatic cancer can also be applied. Surgical treatment Surgical treatment occupies a special position in the comprehensive treatment of bone metastases, especially when bone metastases cause pathological fracture, spinal instability and spinal cord compression. (1)Surgical treatment of limb bone metastases:According to different parts and scope of lesions, corresponding treatment methods are selected. For the fracture of limb stem, the most suitable method is to use interlocking intramedullary nails for internal fixation, and can get out of bed at an early stage after surgery. For femoral rotor fractures, Gamma nails, Ziekel nails or reconstruction nails should be used for internal fixation, and the bone metastasis should be resected during surgery, and the bone defects can be plugged with bone cement, which can assist the internal fixation to fix the fracture and improve the mechanical strength of the tumor bone; for proximal joint fracture, artificial prosthesis replacement is preferred, and the femoral neck fracture can use the femoral head with a long handle or total hip replacement; it is predicted that pathological fracture may occur, and preventive internal fixation can be given to those who may suffer a fracture. The patient can be given prophylactic internal fixation. (2) Surgical treatment of pelvic metastatic tumor: when the metastatic tumor involves the acetabulum and sacroiliac joints and affects the patient’s walking, surgical treatment is needed. According to the different parts of acetabular lesions, the patients should be categorized and treated with corresponding surgical methods. Type I:The acetabular apex and medial wall are intact, and the acetabulum is damaged under the acetabulum and in the anterior and posterior direction, which can be treated by total hip replacement, and the defect after tumor resection can be plugged by bone cement. Type II:The defect of the medial wall of the hip, first fill the defect area with cemented metal mesh, then lead the stress to the acetabular rim through the metal cup, and then install the acetabular prosthesis. Type III: Defects of the outer rim and apex of the acetabulum, the defect can be filled with bone cement, and multiple Schnee pins are driven into the normal bone in a fan shape from the outer rim of the acetabulum to direct the stress to the normal bone. Type Ⅳ:The acetabulum is widely destroyed, but the mass can be completely resected and treated, such as after thyroid tumor resection, only a single pelvic metastasis case can be used for internal hemipelvic resection, artificial hemi-pelvic replacement, combined with postoperative radiotherapy if necessary, most of the patients can walk with a single crutch. For the metastatic tumor can be widely resected, and the tumor osteolysis is not obvious, the patients with less impact on the mechanical strength of the bone can also choose the tumor bone resection, high temperature and high pressure inactivation and reimplantation reconstruction, and the iliac wing part of the tumor can be given to the implantation of the bone or combined with the internal fixation surgery after resection. (3) Surgical treatment of spinal metastases: the indications for surgery of spinal metastases are as follows: ① spinal instability. ② Those whose pain cannot be relieved after radiotherapy, or those who have relapsed or continue to worsen after radiotherapy or chemotherapy. Those with progressive spinal cord or nerve function impairment. ④ The primary tumor is unknown or the histopathological diagnosis is unknown, and surgery is performed at the same time as frozen biopsy. Those who have the above conditions and the estimated survival period of the patient is more than 6 months. Traditional surgery for spinal metastatic tumors can be divided into anterior surgery and posterior surgery. If the tumor is mainly located in the spinous process, vertebral plate, or pedicle, and the spinal cord compression comes from the back, or if more than 2 consecutive vertebrae are involved, then posterior surgery is preferred, with laminectomy and decompression followed by pedicle fixation system. If the tumor is mainly located in the vertebral body and the compression is from the anterior, anterior surgery should be used. Regardless of the method, strong internal fixation should be applied after decompression, especially in cases with long estimated survival. Metastatic cancer usually arises within 2 years of the appearance of the primary lesion, but in many cases metastatic cancer appears clinically prior to the primary cancer. Other bone, lung/liver metastases subsequently appear. Radiotherapy for bone metastatic cancer often achieves local control and pain relief. Hormonal modulation of hormone-sensitive tumors is beneficial for both surgical and non-surgical patients. Surgical treatment, including prophylactic internal fixation of areas where pathological fractures may occur or treatment of those that have already occurred, can improve quality of life. The treatment plan for bone metastases needs to be agreed upon multidisciplinarily (the discipline of tumorigenesis, the surgical discipline of the primary tumor, the surgical discipline of orthopedics, and the radiological discipline, among others), and it is important to correctly recognize and evaluate the biology of the tumor, the general condition of the patient, the expected survival rate, the efficacy and advantages and disadvantages of the various treatments, as well as their duration and prognosis. When deciding whether to administer destructive treatment or to abandon treatment, one should consider and treat it with special care. In conclusion, with the development of chemotherapy, radiotherapy, biotherapy, as well as orthopedics and surgical oncology, the concept of treatment of bone metastases has been significantly updated. The pessimistic view that bone metastases are a terminal disease and treatment is abandoned has become a thing of the past. The traditional point of view should be changed, for some suitable cases, aggressive surgical treatment will get better therapeutic effect, but the treatment of bone metastases should also follow the principle of comprehensive treatment of tumors, and it is irresponsible to favor one method and neglect another. Only in this way can we achieve the goal of treating bone metastases: to relieve patients’ pain, to improve their quality of life, and to prolong their lives as far as possible.