What are Containment Antibodies? During pregnancy, the antibody is produced by maternal exposure to paternal antigens and binds to placental cell surface antigens, thus blocking the maternal cytotoxic T cells from launching an immune attack on the embryo and protecting the fetus and maintaining the pregnancy. The relationship between blocking antibodies and habitual miscarriage About 80% to 90% of women with habitual miscarriage do not have such specific blocking antibodies measured and have unsuppressed cytotoxic cells in their bodies. These cells can act directly on the placenta or indirectly by releasing inflammatory mediators that can damage the fetus or placenta, leading to the onset of miscarriage. What is lymphocyte active immunotherapy? Lymphocyte active immunotherapy involves the injection of lymphocytes from the husband or a third party into the body of a patient with habitual abortion to induce the production of an alloimmune response and the acquisition of closed antibodies and microlymphocytotoxic antibodies. In this way, the maternal immune system does not develop an immune attack on the fetus, increasing the success rate of another pregnancy. What are the advantages of activated lymphocyte active immunotherapy over general lymphocyte active immunotherapy? 1. A small amount of blood is drawn at one time, which is enough for a full course of treatment. The lymphocytes are isolated from 40ml of the husband’s or third party’s blood, activated and proliferated in vitro, immunized with the proliferated lymphocytes, and the remaining lymphocytes are frozen and stored. It can be maintained for about 1 year and injected more than 10 times. 2. Better therapeutic effect. Activated lymphocytes have higher purity and stronger activity, and are more likely to stimulate the closed antibodies in the patient’s body. 3.Ensure a healthy supply. When the husband suffers from infectious diseases such as hepatitis B and is not suitable for blood supply, activated lymphocytes can solve the problem of not being able to find a third party for blood supply. What is activated lymphocyte active immunotherapy? Activated lymphocytes are lymphocytes extracted from the husband’s or third party’s blood, isolated, and stimulated with cytokines in vitro to make them activate and proliferate. Lymphocytes of higher purity and activity are obtained and are more likely to stimulate the production of closed antibodies when injected into the patient. The indications for active immunotherapy with activated lymphocytes are: 1. Those who cannot turn positive with closed antibodies after active immunotherapy with lymphocytes. 2.The blood donor is not convenient to come for fresh blood every time. 3.Husband suffering from hepatitis B, hepatitis C, AIDS, syphilis, tumor and other diseases, not suitable for blood supply. Precautions before treatment: 1. Those who have a history of habitual abortion and are negative for closed antibody (APLA) are required to undergo active immunotherapy with lymphocytes. 2. The blood donor should be perfected for hepatitis B, hepatitis C, HIV and syphilis before the patient’s treatment. 3. The blood donor should preferably be the husband of the patient. If the husband is not suitable for the blood donor, the next choice is someone who is related to the husband, the next is someone who is not related to the patient, and the last is someone who is related to the patient, and the blood donor can be both male and female.