Itching all over the body after drinking hyperthyroidism medication needs attention and should be discontinued if necessary. The current selection of hyperthyroidism medications is small, usually only methimazole and propylthiouracil, and some patients do experience a rash as well as itching after taking the medications. If itching occurs while taking these two medications and is severe, it is recommended to discontinue the hyperthyroidism medications and then use anti-allergy medications such as cycloheximide, cetirizine, and topical application of glyburide lotion under the guidance of a dermatologist for symptomatic treatment. After the itching has improved, other options such as radioactive iodine-131 therapy or surgery should be chosen to treat hyperthyroidism. Patients with hyperthyroidism are prone to allergies. Some patients tend to develop rashes and itching about 2 weeks after taking the medication, so patients should observe themselves while taking the medication. If discomfort occurs while taking the medication, it is recommended that the medication be discontinued in a timely manner and that other forms of treatment be used when the symptoms improve. In addition to using oral medication, radioactive iodine-131 treatment is also an option for hyperthyroidism. Radioactive iodine-131 treatment is outstandingly effective and patients usually do not experience drug allergy or drug rash during its use, but it is still important to be more observant, as some hyperthyroid patients are prone to skin diseases themselves. If neither medication nor radioactive iodine-131 therapy is suitable for the patient and the patient has an indication for surgery, subtotal thyroidectomy may be performed. In addition to itchy body, hyperthyroid patients are also prone to other drug side effects after taking medication. The more common ones are leukopenia, and some patients can develop severe leukopenia or even granulocyte deficiency, which also requires discontinuation of medication and treatment with radioactive iodine-131. Patients with hyperthyroidism are also prone to liver function abnormalities, which should also be discontinued in time for active treatment with other modalities.