1.Symptoms and signs 1.Systemic symptoms: 94% are single lesion, slow onset, may experience pain in the affected area for several months or 1-2 years, patients may have tiredness, loss of appetite, about 37%-80% have different degrees of fever in the afternoon, night sweats and weight loss and other systemic symptoms of toxicity, a few cases may not have the above systemic symptoms. 2. Local symptoms and signs ① joint dysfunction; ② joint swelling; ③ pain; ④ cold abscess or sinus tract; ⑤ joint deformity; ⑥ neurological dysfunction. Laboratory tests: 1) routine blood count and sedimentation test; 2) c-reactive protein; 3) liver and kidney function tests; 4) tuberculin purified protein derivative (PPD) test and its significance: 4.7%-14% of adult patients with osteoarthritis are negative for PPD; 5) culture of Mycobacterium tuberculosis (50% positive rate) and smear staining (11%-20%); even if the test is negative, the test is still negative. Even negative cases cannot be excluded from osteoarticular tuberculosis. 6. Pathological histological examination. Imaging diagnosis 1.X-ray examination: X-ray abnormalities usually appear only when the bone destruction reaches 0.5CM or more, and joint space narrowing occurs in the early stage of septic arthritis. 2.CT examination: If necessary, enhanced and three-dimensional reconstruction examination can be performed, which can provide a basis for the surgical route due to the high spatial resolution. 3.MRI examination: synovial tuberculosis; tuberculous lesions inside and outside the spinal cord.