Botox is widely used as a muscle power regulator in medical aesthetics, and this biological agent can effectively reduce power wrinkles, but the continuous appearance of “zombie face” celebrities has caused negative effects on beauty seekers. So, is it really true that Botox will cause zombie face? In fact, whether or not facial stiffness will occur after Botox injection is related to many factors, such as the choice of agent (imported or domestic), the doctor’s skills and the sensitivity of the candidate to the drug. The selection of the agent and the doctor’s skill are controllable factors, while the individual differences of the patient are relatively uncontrollable (but after one injection, the patient’s reaction to the drug can be adjusted accordingly, which can be controlled at this time). The internationally accepted standard is for Botox to achieve a relative power balance rather than complete muscle paralysis, and if the latter occurs, a zombie face is sure to occur. I have summarized the following 6 principles on how to avoid zombie face by administering Botox to reduce the incidence of zombie face. 1, site: is to be injected precisely into the wrinkle-generating muscle, from the source to reduce muscle power. 2, dose: to control the injection dose according to individual differences, with the smallest dose of coordinated power balance, to minimize the chance of controlling the occurrence of zombie face. 3.Levels: The injection level is divided into three levels: intradermal, subcutaneous fat and intramuscular. Different injection levels can be chosen according to different parts of the body, and in principle, the more superficial the muscle is, the shallower the level of injection. 4, concentration: muscle strength to use high concentration, small strength to use low concentration, the lower the concentration of drug dispersion, the greater the chances of entering the non-targeted muscle will increase. 5, muscle strength: generally male muscle strength will be larger, the required dose will also be larger. 6, synergistic and antagonistic muscles: when we do expression is not only a muscle caused, but multiple muscles synergistic or antagonistic generated, and each person’s synergistic or antagonistic muscles are not completely consistent, there are large differences. For example, some people have wrinkles in the dorsal part of the nose when they smile while others do not. Therefore, treatment for individual differences will be a good way to avoid inconsistent expressions. The method and effects of Botox injections for each area will be explained in detail later.