Since Dr. Jean Carruthers of Canada first reported that Botox injections have the function of removing wrinkles in 1992, Botox injections have been accepted by people for its little trauma, few side effects and reliable effects, and have been widely used all over the world. At present, botulinum toxin type A in the international market mainly includes Botox from the United States, Dysport from the United Kingdom, Hengli from Lanzhou and Cs-Bot from Japan. From the point of view of clinical effect, Botox is comparable to Hengli BTXA in China, while 1U of Botox is equivalent to 3~4U of Dysport. Among them, Hengli Botulinum Toxin A (BTXA) produced by Lanzhou Institute of Biological Products is the only Botulinum Toxin preparation approved for production and sale in China at present. Botulinum toxin is through the action of motor nerve endings and neuromuscular junction, inhibit the release of acetylcholine, that is, blocking the transmission of the medium between the neuromuscular, causing muscle flaccid paralysis or even atrophy in order to achieve the therapeutic purpose of removing wrinkles and muscle size reduction. In cosmetology, it is mainly used to remove wrinkles, such as forehead lines, frown lines, crow’s feet at the corners of the eyes, and horizontal lines on the back of the nose, and to slim the face and legs. The purpose of face slimming is achieved by injecting Botox into bilateral biting muscles to make them atrophy and become smaller; injecting into calves to improve the appearance of calves and become slimmer; changing the shape of eyebrows; making eyes bigger; correcting the drooping tip of the nose; and correcting the short upper lip and the gummy smile. It can also be used to treat armpit odor and hyperhidrosis of hands and feet. Due to the different purposes of various treatments, the efficacy can generally be maintained close to half a year or so, and face slimming can be up to about a year. One of the reasons for the short efficacy of botulinum toxin injections is the production of antibodies, which occurs at a rate of 3 to 5% and can last for about three years, so frequent and large injections in a short period of time should be avoided. The dosage used for cosmetic purposes is very small, and side effects are generally rare. There may be mild swelling at the injection site and rare ecchymosis, which will disappear quickly. Very few people will have allergic reactions and should stay in the hospital for a short period of observation after receiving the treatment. About the safety of Botox for pregnant women: Although there is a report that a pregnant woman received the whole Botulinum toxin A treatment during pregnancy without any adverse reactions, there are also reports that Botulinum toxin injections in individual pregnant women led to miscarriages, preterm births, and animal experiments also led to malformations. Therefore, for safety reasons, it is recommended that Botox should not be used 2 weeks before pregnancy and during pregnancy. Precautions: Those who receive Botox injections should not use aspirin, vitamin E, beta-blockers and aminoglycoside antibiotics such as gentamicin, butylkanamycin, streptomycin, neomycin and so on for 2 weeks before and after the injection. In order to achieve better therapeutic results, in addition to the selection of agents that meet the requirements of national standards, there are strict requirements for the storage and preparation process of this preparation, which is one of the reasons why the same drug can have different effects. In addition, the applicator’s familiarity with anatomy and the precision of the injection site also play a crucial role in the treatment effect and the number of side effects.