In the advanced stage of diabetic foot, there may be deep infection of the foot accompanied by bone tissue lesions or abscesses, limited gangrene, and gangrene of the whole foot, which may vary from patient to patient. Diabetic foot refers to infection, ulcer formation and deep tissue damage in the lower extremities of diabetic patients due to combined neuropathy and varying degrees of vasculopathy. The condition can be assessed based on blood perfusion to the foot, ulcer size, ulcer depth, tissue loss, infection and foot sensation. If the condition is not well controlled and progresses to the advanced stage of diabetic foot, there may be manifestations of deep foot infection with bone tissue lesions or abscesses, limited gangrene, and gangrene of the whole foot, as well as pain and muscle atrophy. Patients with diabetic foot should seek timely medical treatment and regular review. In daily life, pay attention to washing feet daily, drying them carefully and avoiding wearing shoes without socks.