The typical manifestation is wandering joint pain, involving the knee, wrist, and stomping joints, causing redness, swelling, pain, and heat, and severe pain when moving, which usually lasts for about one or two months and subsides. In the meantime, the heart is unknowingly invaded, involving the endocardium of the inner surface of the heart, the myocardium of the heart wall, and the pericardium of the outer surface of the heart, causing inflammation of the whole heart, so it is called rheumatic all-heart disease, and the heart is severely damaged in children and adolescents around the age of 10, while the heart is less damaged in adults. Therefore, most of them have the disease at the beginning when they are teenagers, and then they have repeated attacks, causing heart valve disease after 1-2 years. Also about half of the children with heart valve disease in the left cloth do not know if they have had rheumatic fever, which is worthy of attention. These patients are likely to have rheumatic fever that is so mild that they do not mind and develop valvular disease after repeated episodes. To prevent the development of valvular disease, universal cardiac screening should be performed in school-aged children to allow for early detection and prevention. For more information on specific prevention methods, see later. Heart valve disease is a disease in which the heart valves are unable to function properly because of damage. The most common type is chronic rheumatic heart valve disease, which is damage to the mitral valve at the entrance of the left atrium into the left ventricle. Under normal circumstances, when the left ventricle contracts, the mitral valve closes tightly and blood shoots completely into the aorta and cannot flow backwards into the left atrium, while mitral valve disease night, the mitral valve cannot close well and blood flows backwards into the left atrium, this disease is called mitral valve atresia insufficiency. In addition, the mitral valve junction is healed by adhesions, so that the mitral valve is narrowed, and when the left ventricle is diastolic, blood cannot enter the left ventricle smoothly, and this disease is called mitral stenosis. When mitral stenosis occurs, blood from the left atrium accumulates on the rough surface of the left heart ear to form wall thrombus. If the thrombus is dislodged and bursts into various parts of the body via the aorta, it leads to vascular embolism, most commonly cerebral artery embolism and extremity artery occlusion. In the case of cerebral artery embolism, limb paralysis can occur, and in serious cases, death can occur. In addition, rheumatic disease can also cause damage to the aorta, resulting in atresia and stenosis of the aortic valve. The latter does not allow blood to enter the aorta smoothly during left ventricular systole, resulting in hypertrophy due to increased load on the left ventricle, while in the former, blood flow backs up from the aorta during left ventricular diastole, causing enlargement of the left ventricle due to massive blood accumulation, thus causing a series of clinical symptoms. In short, chronic heart valve disease gradually worsens over several years and eventually leads to chronic congestive heart failure and even death of the patient.