If oral azithromycin treatment is not effective for most mycoplasma infections, it often indicates that the mycoplasma is resistant to azithromycin or recurrent infections, the patient can take the following treatment measures: 1. Retrieve urethral secretions or leucorrhoea for mycoplasma culture plus drug sensitivity test. 2. Choose sensitive antibiotics for treatment according to the results of drug sensitivity test, which is more targeted and better. The first of these is the use of the newest and most popular antibiotics.