The “danger triangle” of the face clinically refers to the triangle formed by the line from the corners of the mouth to the root of the nose on both sides. If an inflammatory infection occurs in the “danger triangle”, improper handling will cause the infection to flow backwards through the facial vein into the cavernous sinus and cause intracranial infection, which can lead to death in serious cases. Small boils and acne in this area, when squeezed with fingers, can cause blood reflux and bacteria can easily enter the deep veins, causing sepsis, sepsis, and even intracranial venous sinuses. Not only will this lead to severe cavernous sinus thrombophlebitis, but it will also be accompanied by severe headache, nausea, vomiting, and even life-threatening brain abscess. When inadvertently squeezing a pimple in the danger triangle, local disinfection and anti-inflammatory treatment can be carried out first to prevent the spread of inflammation and discomfort to seek medical attention. Antibiotic drugs such as mupirocin and erythromycin can be applied locally under the guidance of a professional doctor to prevent the spread of bacteria to the center, and antibacterial drugs such as cephalosporins, azithromycin and minocycline can be taken orally in combination. If the patient has acne here and has triggered other symptoms, such as swelling and pain area expansion, fever, etc., should promptly seek medical attention and should not be taken lightly.