The treatment of severe chronic obstructive pulmonary disease is mainly as follows: 1, quit smoking; 2, once a year influenza vaccination (the end of October in the north); 3, pneumococcal vaccination; 4, long-term oxygen therapy, oxygen should be more than 15 hours a day; 5, under the condition of oxygen, strengthen the activities of the upper and lower limbs; 6, drug therapy: inhaled tiotropium bromide 1 inhaled once a day, can be added to the Shu Li Di (50/ 500). Recently, there is a new drug indantatrol, which can be inhaled once a day, with this drug should be discontinued when the use of Schlitzel; 7, if the effect is still not obvious after treatment can be evaluated to see if pulmonary decongestion therapy. 8, long-term chronic respiratory failure can be treated at home with non-invasive ventilator therapy.