Smoker’s disease is a cerebrovascular disease characterized by chronic progressive stenosis or occlusion of the terminal internal carotid arteries and the beginning segments of the anterior and middle cerebral arteries bilaterally, and secondary to the characteristic formation of an abnormal vascular network at the base of the skull. The etiology of smog disease has not yet been elucidated, and its diagnosis requires the exclusion of known causes of smog syndrome or smog-like disease such as atherosclerosis, autoimmune diseases, meningitis, brain tumors, Down’s syndrome, neurofibromatosis, etc. Medications used in the treatment of smog include vasodilators, antiplatelet drugs and anticoagulants, which have some clinical efficacy, but their effectiveness has not been confirmed by clinical trials. For patients with ischemic symptoms, drugs such as aspirin or Bolivar can be considered, and antiepileptic drugs can be given to patients with epilepsy. There are no effective drugs to reduce the rate of bleeding in patients with smog.