Amoxicillin is a penicillin antibiotic that is mainly used for bacterial infections, and amoxicillin itself does not usually have an effect on the vaccine. Taking amoxicillin usually indicates that the patient has an infection of his or her own, and therefore it is not recommended that patients receive the new coronavirus vaccine if they have an untreated infection. It is recommended that such patients wait until they are cured and stop taking anti-infective medications before receiving the new coronavirus vaccine to avoid the possibility of adverse reactions such as mild rash, malaise, dizziness, headache, and low-grade fever. And it may also lead to persistent aggravation of the disease symptoms of the patient’s own infection, which is not conducive to recovery. In addition to those who are taking amoxicillin for infection, other groups such as women during pregnancy, those who are allergic to any of the components or adjuvants in the vaccine, those who have experienced allergies in the past when receiving similar vaccines, and those who have experienced acute allergic reactions, respiratory distress, angioneurotic edema, and other severe allergic reactions should not receive the vaccine. The new coronavirus vaccine is also contraindicated if the patient suffers from severe neurological diseases such as Greenbrier syndrome, demyelinating disease, epilepsy, fever, acute disease, acute exacerbation of chronic disease, and patients with severe chronic diseases.