Cirrhosis is caused by diffuse degeneration and necrosis of hepatocytes from a variety of causes, with proliferation of fibrous tissue and nodular regeneration of hepatocytes, and gradual destruction of the structure of liver lobules and blood circulation, causing the liver to deform and harden. The common causes of cirrhosis are viral infection, alcoholism, autoimmune, metabolism, etc. Cirrhosis requires systemic treatment including general treatment, etiological treatment, anti-fibrosis, anti-inflammatory, antioxidant and hepatoprotective therapy and treatment for complications. General treatment: Adequate rest and proper diet are essential for the regeneration and recovery of liver cells. Etiological treatment: For example, alcoholic cirrhosis must be treated by abstaining from alcohol, hepatitis B and C require antiviral treatment according to the condition, and hepatomegaly can be treated by copper detoxification. Anti-fibrotic treatment: In hepatitis B cirrhosis, fibrosis and even cirrhosis can be reduced from liver histopathology after antiviral treatment with IFN-a or nucleoside (acid) analogues. Therefore, antiviral therapy is the basis of antifibrotic therapy. Several anti-fibrotic TCM formulations have shown some efficacy in experimental and clinical studies, but further large-sample, randomized, double-blind clinical trials with emphasis on liver histological findings are needed to further validate their efficacy. Anti-inflammatory, antioxidant and hepatoprotective therapies: glycyrrhetinic acid preparations, reduced glutathione, s-adenosylmethionine, silymarin preparations, polyunsaturated lecithin preparations and bicyclic alcohols have different degrees of anti-inflammatory, antioxidant and hepatocyte membrane and organelle protection effects, and their clinical application can improve liver biochemical indicators .