High blood creatinine and blood uric acid can be seen in physiological increase, after removing the causative factors, generally can be returned to normal, without special treatment. If they are pathologically elevated, we need to find the cause and then treat the cause and symptoms; if they are acutely elevated, we can actively control the triggering factors and take medication and dialysis; if they are chronically elevated, we can treat them with medication, dietary regimen, and dialysis, and so on. Physiological increase of blood creatinine and blood uric acid is common after consuming large amount of meat and seafood, or after strenuous exercise, which can be recovered after removing the triggers, and generally do not need special treatment. Pathological increase of blood creatinine and blood uric acid is common in acute and chronic renal failure, primary glomerular disease and hyperuricemia. 1. Acute elevation can be due to the original renal insufficiency combined with infection, usually can actively control the triggering factors, such as the use of ceftazidime and other anti-infective, but also can take febuxostat and so on to reduce uric acid; serious need for dialysis treatment. 2. Chronic elevation, feasible drug therapy, dietary modification and dialysis and other treatments. (1) Drug treatment: kidney detoxification drugs such as Bailing capsule, urethane granules, etc.; uric acid-lowering drugs such as febuxostat. (2) Dietary modification: Improve dietary habits, minimize the intake of purine and fat-rich foods, such as seafood, nuts, etc., and take low-salt, low-fat and high-quality protein diets, such as fish and meat. (3) Dialysis: Dialysis treatment, including hemodialysis or peritoneal dialysis, is needed when blood creatinine and urea nitrogen are very high. If you find high blood creatinine and blood uric acid, it is recommended to consult a doctor in time and follow the doctor’s instructions to standardize the diagnosis and treatment, do not self-medication.