Cytomegaovirus (CMV): also known as cytomegaovirus, a herpesvirus group DNA virus, CMV infection in the population is very widespread, the infection rate of adults in China reached in more than 95%, usually recessive infection, most infected people do not have clinical symptoms, but under certain conditions invade multiple organs and systems, and produce serious diseases, the virus can invade the liver, lung, kidney, saliva, breast and other glands, and multinucleated leukocytes and lymphocytes. The virus can invade the liver, lungs, kidneys, salivary glands, mammary glands and other glands, and multinucleated leukocytes and lymphocytes, and can be detoxified from saliva, breast milk, sweat, blood, urine, semen, uterine secretions and many other places for a long time or intermittently. It is transmitted through multiple routes such as oral, reproductive tract, placenta, blood transfusion or organ transplantation. The Department of Pediatrics, Xiamen University Affiliated Success Hospital CMV infection in pregnant mothers can invade the fetus through the placenta causing congenital infection and in a few cases causing premature birth, miscarriage, stillbirth or death after birth. Jaundice, hepatosplenomegaly (the etiology of infantile hepatitis syndrome), thrombocytopenic purpura and hemolytic anemia may occur in children. Surviving children are often left with permanent mental retardation, neuromuscular motor deficits, deafness and chorioretinitis optica. However, there is no need to worry about the low incidence. Infants can be infected through the birth canal, mostly as a subclinical bed infection with mild symptoms, sometimes seen as a mild respiratory disorder or liver damage. Infections can also be acquired through suckling, kiss, sexual contact, blood transfusion, etc. In recent years, it has been found that in many newborns, jaundice does not subside, or jaundice recedes but reappears pathologically jaundice is associated with CMV infection. Severe CMV infection in some cases leads to hepatitis, cholangitis, resulting in biliary atresia obstruction, white clay-like stools, and liver failure. Early surgical treatment is required, and once surgery is missed the prognosis is poor. Some can lead to hyperbilirubinemia and even nuclear jaundice, producing permanent intellectual; motor impairment. Others have concurrent immunodeficiency and recurrent serious infections in infancy and childhood, which can even be life-threatening. (1) Viral isolation, which is the “gold standard” for the diagnosis of active H C M V infection, and the use of short culture followed by detection of viral antigens can shorten the detection time; ( 2) viral particles and giant cell inclusion bodies ( low positivity rate); ( 3) viral antigens, such as early rapid-onset antigens, early antigens and p p 6 5; ( 4) specific viral genes (4) specific viral genes (m RNA, DNA), which should be quality controlled to reduce false positives by PCR method. Serum HCM V DNA levels correlate with the severity of HCM V infection in neonates and immunosuppressed individuals, and quantitative analysis is mainly used to monitor viral activity and antiviral efficacy in immunosuppressed individuals; ( 5 ) specific antibodies, double serum anti-HCM V Ig G titer >_4 times higher or anti-HCM V IgM positive has diagnostic significance. G C V is an open-loop nucleic acid analogue and is the first-line drug for severe H C M V infection in children, with an oral bioavailability of only 6% and treatment requiring intravenous administration.G C V is mostly eliminated from the kidneys in its prodrug form, and the concentration in the cerebrospinal fluid is usually 25% to 70% of the plasma concentration. The treatment regimen is based on adults: induction therapy: 5 m g/k g every 12 hours for 2-3 weeks; maintenance therapy: 5 mg/k g once daily for 5-7 days. The author’s experience is that the induction period is monitored for urinary detoxification, and maintenance therapy can be entered after a negative urinary detoxification. Many people think that no treatment is needed, anyway, so many people are infected is fine, but once the disease develops, the serious results often lead to family disaster results. Overall statistics show a prevalence of 5% in newborns and 1-2% of serious organ damage after infection.