Creutzfeldt-Jakob disease is a chromosomal abnormality, so many patients fear that having a child will be hereditary, and many clinicians even mistakenly believe that there is a chance of heredity. However, large-scale clinical data shows that the chances of reoccurrence of Creutzfeldt-Jakob disease in the offspring of a person with Creutzfeldt-Jakob disease are very small compared to the natural occurrence of Creutzfeldt-Jakob disease itself. In layman’s terms, the disease is not hereditary. Experts speculate that the main reason for this is that xx, xy gametes are inherently difficult to produce and are also very difficult to combine with eggs, so the chances of inheritance are very low and it is rare to see cases of inheritance.