I. What is non-invasive DNA prenatal testing technology? Non-invasive DNA prenatal testing is a new fetal chromosomal disease detection technology that is safe, accurate and fast. This technology only requires the drawing of venous blood from the pregnant woman to accurately determine whether the fetus has Down’s syndrome, Edward’s syndrome, Patau’s syndrome and other chromosomal disorders. Second, what is the principle of non-invasive DNA prenatal testing? Based on the above findings, the non-invasive DNA prenatal testing technology can analyze the fetal DNA information contained in the venous blood of pregnant women using new generation sequencing technology and bioinformatics methods to accurately determine whether the fetus is suffering from chromosomal disorders. The eugenics and genetics department of Guangxi Maternal and Child Health Hospital, Meng Dahua 3. For whom is the non-invasive DNA prenatal testing technology applicable? 1.Pregnant women aged 35 or above; 2.Pregnant women with high serological prenatal screening (Down’s syndrome screening); 3.Pregnant women who are virus carriers (such as hepatitis B virus carriers); 4.Pregnant women who are carrying IVF or other precious children; 5.Pregnant women who are Rh negative; 6.Pregnant women who are not suitable for invasive prenatal diagnosis due to placenta previa or other reasons; 7.Pregnant women who do not want to undergo invasive prenatal diagnosis due to excessive psychological pressure; 8.Pregnant women who do not want to undergo invasive prenatal diagnosis due to high psychological pressure. Pregnant women who are unwilling to bear the risk of invasive prenatal diagnosis due to excessive psychological pressure. Advantages of non-invasive DNA prenatal testing technology 1. Safety: no trauma, no abortion, no risk of infection; 2. V. Limitations of non-invasive DNA prenatal testing technology The test is an accurate screening technology with an accuracy rate of 99%, it is a prenatal test for common chromosomal abnormalities, fetal chromosome 21 trisomy, chromosome 18 trisomy and chromosome 13 trisomy, which can only exclude fetuses suffering from chromosome 21, 18 and 13 trisomy; it cannot