The obsessive-compulsive cleanliness disorder is a type of compulsive actions and behaviors, mostly stemming from the fear of contamination of oneself with unclean objects, such as bacteria, viruses, dirt, etc. Individuals repeatedly show signs of cleaning their hands, washing clothes, disinfecting furniture, etc. A good way to treat obsessive-compulsive cleanliness disorder is mainly a combination of medication and psychotherapy taken in the clinic, which can lead to a greater improvement in the prognosis of patients with obsessive-compulsive cleanliness disorder, but the intensity should also be noted in the treatment process to avoid over-treatment, which is an aggravation of symptoms. I. Psychotherapy: 1. Cognitive comprehension therapy: explain to patients the reasons for the emergence of obsessive-compulsive disorder, so that patients have the correct knowledge of the disease, clear and not organic disease, after active treatment will have a better outcome, even if the symptoms are not reduced in a short period of time, will not develop in a more serious direction, not to mention the emergence of other complications endangering life, while building the patient’s confidence to overcome the disease; 2. Cognitive behavioral Treatment: including exposure and reaction prevention, exposure therapy requires patients to face the things or behaviors that cause painful reactions, through relaxation training, so that the symptoms are relieved, reaction prevention requires patients to postpone, reduce or even give up behaviors that cause compulsions, patients with cleanliness compulsions can shorten the time of hand washing, reduce the frequency of hand washing, or even give up hand washing, you can make a reward mechanism to gradually increase the difficulty, in the maintenance treatment Play a better role; 3, full irrigation therapy: also known as exposure therapy in the clinic, so that the patient directly into the most unacceptable environment, and without any psychological preparation in the early stage, face the impact of the visual, but this treatment has a certain risk, the need to have professional first responders present, ready to respond to unexpected situations; 4, aversion therapy: so that the patient to establish a conditioned reflex, the need to abstain from Bad behavior through a combination of punishment or aversion ideas, you can choose electroshock aversion therapy, drug aversion therapy, rubber band therapy, etc. Second, drug therapy: preferred SSRI drugs, such as paroxetine, fluoxetine, sertraline, etc., so that the central nervous system 5-HT concentration increases, so as to achieve therapeutic effects, second-line treatment drugs such as chlorpromazine, as well as aripiprazole, risperidone, quetiapine, but the drug side effects are large, and may only have an effect on part of the patients with OCD, so it is necessary to use the drug under the guidance of a doctor reasonably to avoid Adverse consequences.