Chronic pancreatitis and acute pancreatitis are different in pathogenesis, pathology, clinical manifestations and treatment. 1. Pathogenesis: Acute pancreatitis usually starts acutely, mostly due to the abnormal activation of pancreatic enzymes caused by overeating, cholelithiasis and other etiological factors that cause the pancreas itself and the surrounding organs to produce digestive effects; chronic pancreatitis is not obvious, caused by genetics, the environment, and other disease-causing factors together. 2. Pathological manifestations: acute pancreatitis is characterized by edema of the pancreatic parenchyma and peripancreatic fat necrosis, and in severe cases, it can develop into hemorrhagic and necrotizing pancreatitis; chronic pancreatitis is characterized by the reduction of pancreatic follicular tissue and fibrosis. 3. Clinical manifestations: Acute pancreatitis is characterized by sudden, gradually worsening persistent abdominal pain, which can be tearing pain, dull pain, located in the upper abdomen, pain can be radiated to the back, accompanied by nausea, vomiting, etc.; Chronic pancreatitis is characterized by intermittent abdominal pain, weight loss, malnutrition, steatorrhea and so on. 4. Treatment: Acute pancreatitis patients should be fasted, intravenous fluid replacement, remove the cause of the disease, inhibit the secretion of pancreatic enzymes, can use octreotide, growth inhibitors and other drugs; chronic pancreatitis treatment is mainly to remove the cause of the disease, control the symptoms, improve the function of the pancreas, the serious need for surgical resection. Acute pancreatitis and chronic pancreatitis can be transformed into each other, and when pancreatitis is suspected, patients should consult a doctor in a timely manner, and should not be treated blindly. The above drugs should be used under the guidance of a doctor.