Patients usually come to the doctor with this question. Major triple-positive means HBsAg, HBeAg, anti-HBc positive, indicating a person with hepatitis B infection, with viral replication in the body, with strong contagiousness, also seen in asymptomatic carriers. Small triple positive refers to the conversion of HBeAg to anti-HBe (natural conversion or after treatment) regardless of the major triple positive or small triple positive, it only represents the degree of viral replication and does not reflect the severity of the disease. The major triple-positive, indicating that the hepatitis B virus is actively replicating in the body, such patients may have infectious blood, saliva, semen, breast milk, cervical secretion, urine, if there is also liver function damage (especially transaminase GPT increased), the first should be isolated, dishes and other tableware at home and separate from the family, regular disinfection, patients using anti-virus, improve the body’s immunity and symptomatic enzyme lowering liver protection The patient should be treated with antiviral measures to improve immunity and symptomatic enzyme reduction and liver protection. For close family members, liver function and hepatitis B virus infection index should also be checked. It is recommended to check hepatitis B virus DNA, liver ultrasound, liver function, etc. According to the actual situation. If the DNA of hepatitis B virus is negative, the virus is basically no longer infectious. If the DNA is negative, the virus is no longer contagious. The change from major triple-positive to minor triple-positive means that the virus is less replicated, less contagious and the condition is improving. Patients with minor triplets must be treated differently, and whether or not they should be treated depends on the circumstances. Theoretically, all patients with small triplets should be treated. However, in practice, they should be treated differently, with some needing timely treatment and others not. The presence of hepatitis B, in any form, is a potential threat to human health and their timely and complete removal is not to be questioned. Some people with small triplets have stable liver function for a long time and no obvious discomfort, but they are eager to turn to negative treatment, spending a lot of money but not turning over, and some are getting worse; some patients with small triplets have long-term fluctuations in liver function, but do not get the right treatment, resulting in the gradual development of the disease, which eventually evolves into cirrhosis.