The first situation is that the HBV-DNA is less than 500 copies per milliliter, and the liver function is often normal. The second situation is the toxic replication in an active state, HBV-DNA> 10000 copies / ml, at this time liver function is often abnormal, due to the virus before the C region gene variation, this situation requires active treatment, in the antiviral treatment, ordinary interferon efficacy is not good, it is recommended to use nucleoside analogues such as adefovir treatment under the direction of a specialist.