Segmental vitiligo usually refers to segmental vitiligo, which is currently more difficult to treat and difficult to cure completely, but not completely hopeless. The difficulty in treating segmental vitiligo is that the onset is faster and usually results in complete pigment loss of epidermal melanocytes, but there is a possibility of cure. The treatment of segmental vitiligo should be carried out in stages and phases. In the early stage to control the disease development, control melanocytes do not continue to be destroyed. To the stable stage, patients need to use oral medication, phototherapy to promote the growth of melanocytes as well as the increase of melanosomes and melanin granules. If there are really no melanocytes, the doctor will give the patient some supplemental melanocytes according to the situation, including self-epidermal transplantation, cell transplantation and tissue engineering skin transplantation.