Ever since the show “Do Not Disturb 2” was staged, many patients have come to the clinic with concerns about their “moles” turning into malignant melanoma (MM). Although there is a variety of information on this subject on the Internet, it is a mixed bag, so I am sending this diatribe to set the record straight. First of all, although the incidence of MM in China has been increasing year by year in recent years, the overall incidence is still much lower than that in developed countries (because of skin type and lifestyle), and the incidence is less than one in 10,000. Our department does not receive a few MM patients a year, and the chance of winning the lottery is comparable. Therefore, most of the “moles” are good people, so we do not need to worry too much about them. Secondly, we need to identify whether it is a “mole” or a “spot”, because most of the “spots” are benign and mainly affect the beauty, while “moles “is likely to become malignant. This is relatively simple. Generally speaking, “spots” are flush with the skin surface, such as freckles, chloasma, and post-inflammatory hyperpigmentation spots. Of course, except for “age spots”, which are called “seborrheic keratosis” and are actually benign skin growths. As for “nevus”, it can be parallel or high on the skin surface, such as freckle-like nevus, intradermal nevus, junctional nevus, etc. Of course, there are no absolutes in medicine, and one type of skin tumor, basal cell carcinoma (BCC), can play the role of an interminable tumor that remains parallel to the skin surface for a long time, and thus may be misdiagnosed as dermatitis eczema, etc. It is only when the looming face is finally revealed that the diagnosis is definitively made by an experienced dermatologist after biopsy. But fortunately, BCC develops slowly and has almost no metastasis, and the recurrence rate after surgery is low, so the risk to our health is limited. Secondly, the part of the “mole” determines to a considerable extent the risk of malignant transformation. For Asian people, pigmented moles at the end of the limbs are most likely to cause malignant changes because of long-term friction, and if they are nail moles that grow under the nails, they should be eradicated early; secondly, pigmented moles on the exposed parts of the head and face may also turn into malignant melanoma if they are exposed to sunlight for a long time. In addition, if a “mole” is stable for a long time without abnormalities, it is generally more likely to be benign; if it increases rapidly or breaks down in a short period of time, accompanied by itching and pain, or if there are satellite foci (small moles) around it, it often suggests the possibility of malignant transformation. Also, the “ABCDE” principle is used to identify whether a pigmented mole is malignant or not; A (asymmetry): if a large pigmented mole is very asymmetrical, it has the possibility of malignant transformation; B (border): edge, a pigmented mole with irregular edge has a high possibility of malignant transformation; C (color): uneven color has a high possibility of malignant transformation. D(diameter): pigmented nevus with a diameter of more than 6 mm has a high possibility of malignant transformation; E(enlarge): pigmented nevus with rapid growth has a high possibility of malignant transformation. In addition, pigmented nevus without hair growth has a higher possibility of malignant transformation than pigmented nevus with hair. Finally, if you find that the “mole” on your body does not match your noble temperament after years of patience, and you are determined to part ways with it completely, laser or surgical treatment in dermatology is certainly a very fashionable and beautiful choice, but please make sure to go to a regular medical institution.