After the movie “Do Not Disturb” was shown, many people went to the hospital to remove moles in horror. First of all, what is a mole? Usually, what people call a mole is basically the medical term for a pigmented mole. The definition in dermatology textbooks is: Mole cell nevus, also known as pigmented nevus, is the most common benign skin tumor in humans. Mole cells usually go through different stages of development, maturation and aging and gradually move from the epidermis into the dermis with age. Moles can be congenital or acquired and can be present at birth, but often begin to appear after the age of two. They can occur anywhere on the skin and mucous membranes of the body. They may appear as flat or slightly elevated macules or papules, or may be hemispherical, papillomatous, or tipped, with a smooth surface, with or without hair, and may be single, several to dozens in number. Depending on the type and content of pigment in the nevus cells, the appearance can be brown, brown, blue-black or black, and the non-pigmented rash is mostly skin-colored. Depending on the location of nevus cells in the skin, they can be classified as junctional nevi, mixed nevi and intradermal nevi. Flat rashes suggest junctional nevi, slightly elevated skin is mostly mixed nevi, and papilloma-like rashes and almost all hemispherical and tipped rashes are intradermal nevi. Moles progress slowly and most have no conscious symptoms. Secondly, do moles need to be treated? How do we face it? Generally speaking, no treatment is needed. If treatment is needed, there are only two cases: one is to remove it for cosmetic reasons; the other is to remove it for fear of malignant changes. For cosmetic reasons, moles need to be removed because the location of the mole is unsightly and affects the appearance or because of superstitious beliefs that it is bad and affects the future; for pigmented moles that are afraid of deterioration, there are several possibilities, which need to be removed as soon as possible and histopathological examination to clarify whether they may deteriorate or have deteriorated and whether they need further treatment: ① congenital nevus cell moles have the possibility of melanoma, so it is appropriate to remove them as soon as possible; ② occurring in the palmoplantar, periaqueductal, armpit ② junctional nevi and mixed nevi in the palmoplantar, periapical, axillary, groin and other friction-prone areas should be considered for surgical excision; ③ nevi should also be surgically excised if there are signs of malignancy: 1) sudden increase in size 2) darkening or mottling 3) surface erosion, ulceration, bleeding or swelling 4) self-perceived pain or itching 5) satellite lesions around the nevus, etc. Finally, how to face or deal with nevi? In the past, there are many methods to remove moles, which are summarized as the following: ① drug to remove moles: chemical erosion, herbal erosion, etc. ② electric cautery to remove moles: electric knife, high frequency ionization, microwave, etc. ③ laser to remove moles: CO2 laser, fractional laser, Q-modulated laser, etc. ④ surgery to remove moles: surgical removal. The first thing to consider is beauty, followed by safety; the first thing to consider is the bad effects of mole removal to prevent deterioration, and safety is the priority pursuit, followed by the need for beauty.