Hyperprolactinemia is a common disease of the hypothalamic-pituitary-gonadal axis. Excessive prolactin interferes with the function of the reproductive glands and is one of the causes of male and female hypogonadism and infertility. Etiology 1, Prolactinoma (Prolactinoma) is the most common cause of hyperprolactinemia, is also the most common pituitary tumor; 2, intracranial tumors or inflammation and other causes of damage to the hypothalamus caused by the decline in prolactin inhibitor, resulting in hyperprolactinemia; 3, idiopathic hyperprolactinemia; 4, Pseudoprolactinoma: Pituitary non-functioning tumors compression of the pituitary stalk and so that the hypothalamus Pseudoprolactinoma: the pituitary tumor without function compresses the pituitary stalk and impairs the hypothalamus-pituitary connection, causing hyperprolactinemia; 5, primary hypothyroidism, hepatic and renal insufficiency, etc.; 6, taking morphine, dondeolimus, 5-hydroxytryptophan, estrogens, contraceptives, etc.; 7, physical stimuli, such as sleep, nipple stimulation, sexual intercourse and other physiological stimuli, can make the PRL temporarily elevated. Clinical manifestations Adolescents are mainly characterized by delayed growth of sexual hair, loss of seminal emission function, and slow growth; adults are mainly characterized by decreased libido, impotence, 5% of patients may have lactation and breast development, and others may have ejaculatory abnormality, semen reduction, or even azoospermia. Diagnosis 1, serum prolactin base value determination of male impotence, low sexual function, elevated prolactin in the blood can be made to make a qualitative diagnosis of high PRL anemia, but this is not enough, with the help of a number of tests to make a diagnosis of the etiology. Normal male serum PRL is 1-20/?g children, more than the high limit of the normal control value is hyperprolactinemia, but due to physiological factors can also make the PRL for a short period of time mildly elevated, so PRL>50/?g / L, must be repeatedly measured; 2, the dynamics of the prolactin test is commonly used to stimulate the test of the TRH, injection of the TRH to observe the changes in TSH and PRL, the results if the PRL adenoma, the PRL adenomas, the PRL adenomas. If the result is PRL adenoma, TSH can appear peak, and PRL peak does not appear; 3, mirex oral test mirex is a dopamine receptor antagonist, oral 10mg mirex, 1 ~ 2h, PRL can reach the peak of the normal PRL peak is 3 times higher than the basal value, if the peak is low, it can be suggested that the existence of lactinoma; 4, pteronasal thin-layer radiograph to understand the pteronasal whether it is enlarged, destroyed; 5, pituitary gland 5. CT scan and magnetic resonance imaging (MRl) scan of the pituitary gland to confirm the presence of tumor. (1) Bromocriptine: Bromocriptine is a commonly used dopamine agonist, which can inhibit the secretion of PRL by promoting the release of dopamine, so that the serum PRL can be reduced to the normal level, thus increasing the serum testosterone level. Conventional treatment is: start to take 1.25mg orally, once between each dinner, 5-7d after gradually increase the amount to 2.5mg, 2 ~ 3 / d, take half a year, generally can make the serum PRL level down to normal, and make the serum testosterone level increase, improve the sexual function and spermatogenesis, and improve spousal fertilization rate; (2) Loxacin Multi ( Norprolac): Rockstar is also a dopamine agonist, but for non-bromocriptine class, can be used for bromocriptine treatment effect is not good or the side effects of the reaction can not be tolerated prolactinoma patients, generally with Rockstar 3?g / d treatment, after 3d changed to 7.5-g / d; (3) Vitamin B6.