Walking after leg pain is often encountered by many middle-aged and elderly people, perhaps most people think that this is very normal, the age of the well! But do you know what? But do you know that this phenomenon may indicate a potential disease – lower extremity atherosclerosis occlusive disease. As the overall living standard of society improves and the population ages, the incidence of lower extremity atherosclerosis occlusive disease and the number of patients with lower extremity atherosclerosis occlusive disease will increase. Etiologically, lower extremity atherosclerosis is mainly associated with hypertension, hyperlipidemia, and smoking, but also with obesity, diabetes mellitus, long-term ambulatory work, and family history. The disease is characterized by an insidious onset in the early stages, but once in the middle and late stages will be due to severe ischemia of the limbs, resulting in severe pain and even necrosis of the affected limbs, a considerable portion of the patients have to undergo amputation, thus seriously affecting the quality of life. Therefore, it is necessary to raise awareness of the symptoms of this disease. In the early stage of the disease, the patient walks the lower limb muscles to increase the need for oxygen, but due to arterial stenosis blood supply is insufficient, so the lower limbs are in a relatively hypoxic state, then anaerobic metabolism occurs, the generation of metabolites, such as lactic acid and other metabolites to stimulate the nerves and the emergence of the affected limbs, especially the calf muscles of the aching sensation. At this time, if the patient sits down for a short break, the soreness can be relieved or disappear, but then again after walking a certain distance the pain will worsen, which is the so-called “intermittent claudication”. This is called “intermittent claudication”. As the arterial stenosis becomes more severe, the patient’s ability to walk shorter distances becomes more tolerable, until he or she finally loses the ability to walk. To the late stage of the disease, the artery may even be occluded, then even at rest the limbs are in extreme ischemia, nerve endings produce severe pain, called “resting pain”, especially at night and in winter and spring when the temperature is lower symptoms are serious, so such patients often can not sleep all night due to severe pain, causing great pain. At the same time, the skin, muscle tissue ischemia so that its vitality is gradually lost, resulting in the emergence of the affected feet, especially toes ulcers or black gangrene, necrosis of the recurrent infections of the parts of the general drugs often can not be controlled, resulting in the so-called “old rotting feet”. It should be reminded that some patients do not pay attention to intermittent claudication because it occurs only after walking a longer distance; many other patients are treated as general low back and leg pain or calcium deficiency and misdiagnosed for a long period of time after the occurrence of intermittent claudication, and individual patients even have orthopaedic surgeries. Therefore, middle-aged and elderly people over 50 years old, especially patients with coronary heart disease, diabetes mellitus, high blood cholesterol, high blood pressure, and men who are addicted to smoking, must be careful when walking and feeling leg pain, and should be considered to the vascular surgery department to exclude whether they suffer from atherosclerotic occlusive disease of the lower limbs.