Patients with AIDS can have toothache. The immune function of AIDS patients is low and local defenses are reduced. The human mouth can be invaded by pathogenic microorganisms such as bacteria, viruses and fungi, which can lead to severe periodontal infections and toothache. Patients with AIDS can have toothache, and if they develop toothache, they can be treated with non-steroidal anti-inflammatory drugs. Depending on the cause of the disease, certain antibiotic medications should be given for treatment. Pay attention to oral hygiene, brush and rinse your teeth frequently. Oral immune enhancers can be given symptomatically to improve the immune function of the body. With the effective drug treatment, the patient’s toothache symptoms will be improved.