Home oxygen therapy for chronic obstructive pulmonary disease can correct hypoxemia, alleviate the deterioration of lung function, help patients improve symptoms such as hypoxia and dyspnea; promote patients to improve sleep quality, increase exercise endurance, improve quality of life, and reduce physical and mental burden; reduce patients’ pulmonary artery pressure, prevent or delay the occurrence and development of pulmonary heart disease, and help improve survival rate and prolong survival period. However, it is important to note that the method of home oxygen therapy must be correct and reasonable to receive good results. If the method of use is not proper, it will not work accordingly. Let’s meet a patient: Old Rong is over 60 years old, has been hospitalized in our department for several times, clearly diagnosed with chronic obstructive pulmonary disease, and insists on using oxygen at home at home. Usually, the time of oxygen use at home varies, but he uses it for more than 15 hours when he feels chest tightness and shortness of breath, and uses it for less hours or even not when there is no obvious discomfort. This increases the time that the body is deprived of oxygen, which is not conducive to physical recovery. The home oxygen therapy we advocate should be long-term home oxygen therapy. Long-term home oxygen therapy agrees that oxygen should be administered for at least 15 hours to achieve a partial pressure of at least 8.0 kPa (60 mmHg) in order to achieve better oxygen therapy results. In practice, due to a variety of factors, very few patients actually receive oxygen for more than 15 h per day, and most patients decide the oxygen flow rate at home. Patients consider 15 h of oxygen per day as the highest goal, without knowing that 15 h is the minimum value that must be achieved daily. So who is suitable for long-term home oxygen therapy? Patients with COPD who are stable after smoking cessation, chest physiotherapy and medication, and who have arterial hypoxemia at rest, i.e., arterial partial pressure of oxygen <7.3 kPa (55 mmHg) or arterial oxygen saturation <88% when breathing room air, are the most important indications for long-term oxygen therapy. However, almost all home oxygen therapy patients use subjective feelings such as chest tightness, shortness of breath, dizziness, and weakness as criteria for hypoxia to determine whether they need oxygen therapy, and only 7.5% know that their SpO2 is <55 mmHg. Incorrect home oxygen therapy can only increase the mental and economic burden of patients. Therefore, home oxygen therapy must be carried out under the guidance of medical personnel, in which the source of oxygen supply, oxygen delivery method, oxygen flow rate, daily oxygen intake time and treatment course should be strictly regulated; home oxygen therapy should be long-term, patients need to adhere to oxygen intake for at least 6 months to obtain better oxygen therapy results; home oxygen therapy should be low-flow oxygen intake, oxygen concentration should be less than 29%, oxygen intake per minute is about 1 -2 liters, but at least 15 hours of oxygen intake per day. Patients should not shorten the duration of oxygen inhalation on their own, because short-term oxygen inhalation will not only fail to correct the oxygen deficiency, but also make the oxygen deficiency more serious due to the decrease of oxygen partial pressure during the interval of oxygen inhalation, which is unfavorable to the control of the disease; during the period of oxygen inhalation, attention should be paid to keep the nasal catheter unobstructed. If the cyanosis is reduced, the respiration is slowed down and stabilized, the heart rate is slowed down or the spirit is improved, it means that the oxygen therapy is effective and should be continued, otherwise it means that the home oxygen therapy is ineffective or ineffective and must be treated in hospital to avoid aggravation.