HPV53 positive virus is transmitted through sexual intercourse, or close contact route, such as infection with HPV53 subtype virus through contact with clothing and utensils contaminated by HPV patients. The infection of HPV 53 subtype is a high-risk virus. The infection of high-risk HPV is very closely related to cervical cancer, and if it is a continuous infection of high-risk HPV, it will cause cervical precancerous lesions and even cervical cancer. Therefore, high-risk HPV virus infection should be treated with drugs for effective intervention under the guidance of a doctor. Normally, you should pay attention to maintain good living habits to avoid sexual life, do proper physical exercise to enhance resistance to disease, abstain from spicy and stimulating foods, and have regular HPV and TCT examinations to prevent cervical precancerous lesions and cervical cancer.