A baby boy, aged only 3 months and from a foreign country, was found to be born with one eyelid defect, exposed eye, cleft nasal surface, exposed nasal cavity and facial deformity. The parents were very anxious and sought medical help to repair the child’s face as soon as possible. In the past month, due to the eyelid defect, the exposed eye was always red and inflamed, so they had no choice but to come to our hospital to seek medical help to repair the deformity as soon as possible and to prevent and control the eye complications and protect the visual function of the eye. The child was admitted to the Department of Maxillofacial Plastic Surgery. The child was in good nutritional condition, and after a thorough examination, the functions of the vital organs of the system were normal, and all laboratory indicators were normal. In order to enable the child to repair the craniofacial deformity as soon as possible, protect the eye function, relieve the psychological pressure of the child’s parents, and also create conditions for the later repair of craniofacial skeletal deformity, after the whole department discussion, review the literature, and make sufficient preparation, Professor Yang Bin performed the eyelid, jaw skin and soft tissue defect repair, nasal repositioning rhinoplasty, and craniofacial cleft repair for the child. The operation went smoothly and the surgical result was good, which enabled the child to form the initial eyelid and nasal form, and the original exposed eye and nasal cavity were covered and protected. Craniofacial cleft is a congenital cleft defect that runs through the skull, orbit, and maxillofacial bones as well as the soft tissues of the skull and face. Craniofacial clefts can take many forms and vary in severity. Although their clinical presentation is bizarre and difficult to describe, most craniofacial clefts follow the line of embryonic development or the gap between craniofacial embryonic protrusions, and they can be unilateral or bilateral, or bilateral with different types of clefts on each side. The orbital fissure is also called orbital nasal fissure. In severe cases, the orbit, nasal cavity, maxillary sinus and oral cavity are interconnected. Principles of surgical treatment of craniofacial cleft: In general, the timing of the revision surgery depends on the severity of the craniofacial deformity and the size of the threat to life function. For mild craniofacial clefts without functional impairment, surgery can be performed at a later date. Delayed surgery allows the surgeon to take advantage of the infant’s rapidly growing skull, facilitating repair surgery and accurate anatomical landmarks. When severe deformities affect function, initial revision should begin as early as safely possible, and early surgical revision has been shown to be beneficial to the child’s healthy development and to prevent functional impairment. Surgical correction in infancy (up to 1 year of age, 1-2 years) is usually limited to soft tissue procedures. Soft tissue fissures require careful layered suturing to avoid depressed scars. In cases of scar contracture or shortening in length, a “Z” plication can be used to reduce tension. The incision should be placed in an area where normal aesthetics can be maintained. Tessier 3 Craniofacial Cleft Revision: Local flap, “Z” plication, upper eyelid flap, or orbicularis muscle flap transfer to repair lower lid defects, early lid repair is absolutely necessary to prevent corneal ulceration. Repair of craniofacial cleft bone defects can be deferred. Early embedded bone grafting may interfere with or impede the growth potential of the craniofacial skeleton, and there is the potential for substantial bone resorption with apposed bone grafting. As the child grows older, plastic repair of the craniofacial skeleton is necessary, which is as important as soft tissue cleft closure. Without good craniofacial skeletal support, soft tissue reconstruction will not maintain good long-term results. The timing of craniofacial bone reconstruction is determined according to the patient’s craniofacial development and dental and jaw growth, and can be arranged at preschool age (5-7 years old) as appropriate, usually after 12-14 years old for osteotomy and bone graft reconstruction to repair skeletal defects or deformities. In the case of craniofacial median cleft with widened orbital spacing, orbital spacing correction is advisable around 5 years of age. Through this case, we would like to remind the parents of children with craniofacial cleft not to be shy to seek treatment, but to come to the plastic surgery hospital as early as possible, as early diagnosis and treatment is beneficial to the repair of the cleft deformity and to the psychologically healthy growth of the child.