1.Brief introduction of congenital craniofacial anomalies: congenital craniofacial anomalies are inherent deformities of the skull, orbit, zygoma, upper and lower jaws and facial soft tissue deformities caused by genetic abnormalities or embryonic developmental abnormalities, often accompanied by functional disorders of the five senses. There are many kinds of congenital craniofacial anomalies, including craniosynostosis, craniofacial cleft, orbital distance widening, craniofacial short deformity and craniofacial anomaly syndrome, etc. In serious cases, it may lead to intellectual developmental disorders and visual impairment. Its treatment is special and complex. The cranial X-ray, CT and MR examinations are helpful for early detection of lesions, early diagnosis, timely treatment and correction of deformities, which not only can correct deformities and restore normal appearance, but more importantly, can eliminate the pathological pressure and obstruction of the craniofacial bones on the brain and the five senses, so that the central nervous system of the brain and the sensory system of the five senses can grow and develop normally, and make the child grow up healthy physically and mentally, and also relieve It also relieves the family of the child of the great psychological pressure and economic burden. 2.Who is prone to congenital craniofacial anomalies? Why? What is the incidence rate? The incidence of craniofacial anomalies varies among different races, and the types of craniofacial anomalies also vary. According to the current literature, the incidence of craniofacial anomalies is relatively high in Caucasians, and the incidence of deltoid head anomalies is relatively high in North African Algeria. The incidence of craniofacial anomalies will not be the same in Chinese and European countries. However, China is a large country with a population of 1.3 billion, and the number of congenital craniofacial anomalies in the population is not rare. Recent studies have shown that the incidence of congenital craniofacial cleft and cleft lip and palate is on the rise worldwide, which is closely related to the rapid development of industrialization, especially nuclear and chemical industries, the destruction of ecological environment and the impact of pollution on human beings. Statistics on the incidence of craniofacial anomalies are only reported by foreign authors. 370 cases of various types of craniofacial anomalies were found among 1809574 newborns recorded in Toronto Children’s Hospital in Canada in 1976, with an incidence of 1:2450. The South Australian Craniofacial Surgery Centre (1961-1975) found 79 cases of craniofacial anomalies in 17,000 newborns, with an incidence of 1:4000. The incidence of congenital craniofacial anomalies in newborns is 1:1500 according to Marchac, a French doctor. -In 2009, there are about 3900~4000 children with craniofacial anomalies among 15.84~16.15 million newborns each year, and this number is increasing year by year in the past and in the future. In this way, there are tens of thousands of patients with such congenital craniofacial anomalies in China. (1) Types of congenital craniofacial anomalies: craniofacial cleft, orbital distance widening, cranial suture premature closure (cranial anomaly), craniofacial asymmetric anomaly, meningocephalic bulge, craniofacial hemangioma, lymphadenoma, neurofibroma, craniofacial bone fiber anomaly proliferation, congenital microphthalmia, ptosis, craniofacial anomaly syndrome. (2) Causes of congenital craniofacial anomalies: genetic factors: one or both parents have anomalies; inbreeding; chromosomal or genetic mutations. Environmental factors: industrial “three wastes”, pesticides, food additives and preservatives contain teratogenic chemicals. Chemical drugs: chemotherapy drugs, certain antibiotics, drugs for psychiatric treatment, hormones, etc. Radioactive radiation: exposure to radiation during pregnancy or exposure to radioactive substances. Physical factors: mechanical pressure, temperature. Biological factors: infection with rubella, cytomegalic, herpes simplex and mumps influenza viruses, toxoplasmosis, syphilis spirochetes during pregnancy. Metabolic and endocrine diseases: mothers with diabetes are prone to malformed children. Other teratogenic causes: alcoholism, heavy smoking, lack of oxygen, severe malnutrition, etc. are all teratogenic. 4.Prevention of congenital craniofacial malformation The prevention of congenital craniofacial malformation should start from its etiology. First of all, we must adhere to the national family planning and eugenics policy, resolutely oppose inbred marriage, strict premarital examination, clear that both parties to the marriage are healthy, no congenital malformations genetic family history, couples of childbearing age, pay attention to maintain good health, do not smoke and alcohol. The early 1-3 months of pregnancy is a critical period for the formation of embryonic body and organ form, which may lead to various congenital malformations if affected by teratogenic factors. These teratogenic factors include: biological factors, radiation, physical factors, chemical drugs and nutritional factors. Therefore, in the early stage of pregnancy, we should avoid exposure to radiation and be careful against various infectious diseases, including syphilis, toxoplasmosis, especially influenza, rubella and mumps caused by rubella, giant cell, herpes simplex and influenza virus. The use of narcotic psychotropic drugs should be avoided. There have been reports that a certain anti-flu drug has the side effect of inducing cleft lip and palate deformities. In general, pregnancy is not advisable when suffering from endocrine and metabolic diseases such as hyperthyroidism and diabetes mellitus, or at least when such diseases are well controlled. Pregnant women should take care to protect their bodies from heavier mechanical impacts. Nutritional status during pregnancy is very important and nutritional enrichment is also an important factor in ensuring a healthy fetus. To prevent congenital malformations, the health of the parents is most important first, if they carry malformation genes or related genes in their bodies they will pass them to the next generation. Currently, chromosomal and genetic examination and analysis can identify some congenital malformation-related gene carriers. Genetic analysis of cells shed in amniotic fluid in the uterus can help detect genes related to congenital malformations, and the presence of fetal malformations can be detected prenatally. Of course, in the future, non-invasive instruments such as high-resolution and high-resolution ultrasound instruments will be able to detect craniofacial and physical malformations in the fetus in utero. Under the current situation that the international and national governments advocate energy conservation and emission reduction, protection of green ecological environment, and harmony between human and nature, our professional medical workers should actively promote and popularize the knowledge of disease prevention and treatment, healthy living, and environmental protection to prevent the occurrence of congenital craniofacial malformations, and indeed create well-being for the general public and families in a large population country like ours, and contribute to the medical and health care, and people’s health and happiness in China Make some contribution.