Ovarian insufficiency (POI) is defined as abnormal ovarian function due to congenital or acquired causes, manifested ü in women under 40 years of age; ü persistent amenorrhea or scanty menstruation for 4 months; two FSH > 40
IU/L (measured more than 1 month apart). The development pattern: normal – occult POI – biochemical POI – obvious POI. In the occult POI stage, the symptoms are: regular menstruation, normal follicle stimulating hormone (FSH) in blood, normal ovulation and decreased fertility; in the biochemical POI stage, the symptoms are: regular menstruation, increased follicle stimulating hormone (FSH) in blood and decreased fertility; and in the obvious POI stage, the symptoms are: irregular menstruation or The development of marked POI is characterized by irregular menstruation or amenorrhea, elevated follicle stimulating hormone (FSH) in the blood, and decreased or lost fertility. Treatment 1. For those who are ready to have children, estrogen or estrogen-progestin sequential treatment should be used in the hope of natural fertility improvement and natural conception; however, there is little chance of reversing this disease and most of them continue to progress to premature ovarian failure, so in the insidious stage or biochemical stage, pregnancy assistance methods should be actively used in the hope of conceiving a baby as soon as possible! 2. Those who do not intend to have children should also be actively treated, starting with small doses of estrogen and sequential estrogen and progestogen in the progressive stage, and hormone supplementation therapy (HRT) should be actively taken in the obvious stage until after normal menopausal age, or even supplementation until after 60 years of age, in order to prevent the occurrence of osteoporosis, atrophy of the genitourinary organs, abnormal blood sugar and lipid metabolism and senile dementia.