Pediatric Diarrhea Overview Pediatric diarrhea is a gastrointestinal syndrome in which the number of stools increases, and/or the nature of the stools changes due to a variety of reasons. Serious illness may appear systemic symptoms of poisoning and water electrolyte acid-base balance disorders, improper treatment can make the disease prolonged, seriously affecting children’s health and growth and development; is one of the main causes of death of children under 5 years of age, the world each year as many as 1.6 million children died of diarrhea. Zinc supplementation therapy 20mg of zinc per day (10mg per day for infants under 6 months of age) for 10-14 days during the acute diarrhea period can shorten the duration of the disease and reduce the severity of diarrhea. 10-14 days of zinc supplementation can reduce the incidence of diarrhea in the next 2-3 months. Biological role of zinc Zinc is a component of more than 200 enzymes and proteins in the body, such as: DNA, RNA polymerase, ethanol dehydrogenase, carbonic anhydrase, alkaline phosphatase, digestive enzymes, and gustatory proteins to improve appetite, promote protein synthesis to maintain the normal function of the digestive tract. The relationship between zinc and diarrhea Zinc on the structure and function of the small intestine has a very important role in animal models, zinc deficiency and intestinal villi mild atrophy, brush border disaccharidase activity decline related to zinc deficiency animals to cholera toxin secondary reaction enhancement, zinc supplementation reversal of zinc deficiency in zinc-deficient small intestinal mucosal sodium water net transfer decline zinc deficiency, intestinal mucosal repair obstacles zinc-deficient animals accompanied by atrophy of the thymus and lymphoid tissues, decreased immune function, so that the susceptibility to diarrhea Increase the formation of a vicious circle, diarrhea and zinc deficiency are causally related to each other in the diagnosis and treatment should be given sufficient attention Reasons for diarrhea zinc deficiency Excessive loss (prolonged diarrhea), insufficient intake (poor appetite), increased need (rapid growth and development), zinc treatment of pediatric diarrhea mechanism. Zinc supplementation accelerates the repair of the intestinal mucosa Increases the level of diastase in intestinal villous epithelial cells Improves cellular immune function Increases appetite in children with growth retardation. Conclusion Oral zinc combined with traditional programs can significantly shorten the duration of diarrhea and reduce symptoms, because zinc can accelerate the repair of the intestinal mucosa, conducive to the restoration of digestive function and to avoid the continued loss of water and electrolytes Enhance the body’s immune function and digestive barrier function, improve the resistance to the infectious agent Enhance the appetite, conducive to the absorption of nutrients, and faster recovery Enhance the body’s activity of a variety of biological enzymes, including digestive enzymes, to facilitate the digestion and absorption of nutrients, and to enhance the activity of the body’s digestive enzymes. Favor the digestion and absorption of nutrients.