After infection with hepatitis B virus, the virus replicates and multiplies in liver cells, and various antigenic antibodies related to hepatitis B virus infection can be detected in the serum, which is medically known as hepatitis B virus test (commonly known as two-and-a-half pair), and the routinely detected ones are: surface antigen (HBsAg), surface antibody (HB?Jan sAb), E antigen (HBeAg), E antibody (HBeAb), and anti-nuclear antibody (HBeAb). Among them, HbsAg positive, HBeAg positive, anti-HBc positive, commonly known as major triple yang; HbsAg positive, anti-HBe positive, anti-HBc positive, commonly known as minor triple yang. Major and minor hepatitis B are not standardized academic terms, but they are widely circulated among patients. Major triple-positive means that the hepatitis B virus is in the replication stage and is more infectious, while minor triple-positive means that the virus has basically stopped replicating, and if the hepatitis B virus is DNA-negative, it is basically no longer infectious. In recent years, it has been found that some patients with minor triplets have positive hepatitis B virus deoxyribonucleic acid (HBV-DNA) in their serum, which is also contagious, proving that there is a mutated strain of hepatitis B virus. The sign of the virus is not parallel to the patient’s condition, and the severity of the condition is consistent with good or bad liver function. During the first few years to more than ten years of infection with hepatitis B virus in early childhood, the virus and the body “coexist peacefully”, the serum shows a major triple positive, the damage to the liver is usually mild, there are some infected people, especially women infected, the virus can be long-term or lifelong and the body “peacefully coexist Some infected people, especially women, can live with the virus “peacefully” for a long time or for life, called “virus carriers”, and can live until they are over 50-70 years old, without obvious symptoms, not necessarily due to liver disease, but mainly as a source of infection. More infected people are 13-23 years old, and due to the maturity of the body’s immune system, they are able to recognize the infected liver cells and respond by clearing them, and a large number of viruses are cleared, while the infected liver cells are also destroyed, and this repeated clearing and destruction process is the body’s own self-limiting healing (self-healing) process. After several years, the virus is basically cleared, the E antibodies in the serum appear, and the E antigen disappears one after another, which means that the patient changes from a major triple yang to a minor triple yang. Unfortunately, about 2/3 of the infected patients cannot completely clear the latent virus in the liver by their own clearance reaction, and the virus replication, clearance and liver repair are carried out repeatedly. The virus is mostly cleared but the liver damage is already quite serious. It can be seen that if the conversion of major triplet to minor triplet is completed before the age of 25 or 30, the process of virus clearance is completed for the organism and the damage to the liver is lighter; while the clearance reaction (continued hepatitis activity and repeated elevation of transaminases) continues, around the age of 40, for most chronic hepatitis B patients, even if they have converted to minor triplet, they have different degrees of liver fibrillation or cirrhosis.